Eleven years ago, the 2015 origins of the open-source project BrainAnnex.org was as a Multimedia Content Management System . Fast-forward to 2021 : the project had a radical makeover with v. 5, and is now a much more general, modular, full-stack technology solution to effectively utilize graph databases. For example, you can opt to install just the python library, if that's all you need. But if you elect to install the entire repo (python library, web API and web app), you will have a UI that includes: a control panel - including search and visualization a plugin-driven web app that you can customize relatively easily The plugin-driven web app is the focus of this entry. More specifically, the existing plugins that come with the standard release, and provide a Multimedia Content Management System This article is part of a growing, ongoing series on Graph Databases and Neo4j Plugin-Driven Architecture A "plugin", i...
NOTE: this entry was inspired by talks I gave at the "Bio-IT World 2025" conference in Boston, and at the "Aging & Gerontology 2025" conference in San Francisco. A VIDEO VERSION also exists (slightly shorter and outdated to Apr. 2025) Life123 is an open-source platform for quantitative interactomics, aiming towards simulations of virtual biological cells or parts thereof – among other things. And it has a slogan: AI and Big Data aren't enough! We also need Dynamical modeling. What does it mean to say "engine for quantitative reactomics"? It means that we perform dynamical modeling of biological systems. And the initial focus is towards eventually creating whole-cell simulations. The platform consists of python libraries, which allow us to do in-silico experiments. Early this year, this project left the beta stage, after a few years of development. Motivation There's a practical motiva...