NOTE: A VIDEO VERSION of this blog entry also exists (slightly shorter and outdated to Apr. 2025) Life123 is an open-source platform for quantitative interactomics, aiming towards simulations of virtual biological cells or parts thereof – among other things. And it has a slogan: AI and Big Data aren't enough! We also need Dynamical modeling. What does it mean to say "engine for quantitative reactomics"? It means that we perform dynamical modeling of biological systems. And the initial focus is towards eventually creating whole-cell simulations. The platform consists of python libraries, which allow us to do in-silico experiments. Early this year, this project left the beta stage, after a few years of development. Motivation There's a practical motivation – and a conceptual one... The practical side is a simple one to state : about 90 percent of clinical-drug development fails . That’s appalling! And ...
(UPDATED SEP. 2025) I have ample evidence from multiple sources that there are strong unmet needs in the area of visualization of graph databases. And whenever there's a vacuum, there's danger of having to deal with vendors circling like vultures - with incomplete, non-customizable, and at times ridiculously expensive, closed-box proprietary solutions. Fortunately, coming to the rescue is the awesome open-source cytoscape.js library , an offshoot of the "Cytoscape" project of the Institute for Systems Biology , a project with a long history that goes back to 2002. One can do amazing custom solutions, relatively easily, when one combines this Cytoscape library with: 1) a front-end framework such as Vue.js 2) backend libraries (for example in python) to prepare and serve the data For example, a while back I created a visualizer for networks of chemical reactions, for another open-source project I lead ( life123.science ) This ...